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Ros1 is highly homologous with alk, and can also regulate normal physiological activities of cells Most of these alk fusions in nsclc patients respond well to the alk inhibitor, crizotinib. The overexpression of both is closely related to the development and metastasis of tumors

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Introduction anaplastic lymphoma kinase (alk) is a tyrosine kinase that can be aberrantly expressed in several tumor types More than 19 different alk fusion partners have been discovered in nsclc, including eml4, kif5b, klc1, and tpr The most common alk rearrangement in nsclc juxtaposes the 5' end of the echinoderm microtubule.

Similarly to alk nsclc, patients with ros1+ nsclc tend to have minimal smoking history and be of the female sex.

Uncover how your treatment may change. Since then, alk has been associated with other types of cancers, including non‐small‐cell lung cancer (nsclc)